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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Sclareolide, Gemcitabine
Phytochemical Name Sclareolide (PubChem CID: 929262 )
Anticancer drug Name Gemcitabine (PubChem CID: 60750 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 266
Ref_1
Pair Name Sclareolide, Gemcitabine
Disease Info [ICD-11: 2C10] Pancreatic cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CASP3 hsa836
Up-regulation Expression CDH1 hsa999
Down-regulation Expression GLI1 hsa2735
Up-regulation Expression PARP1 hsa142
Down-regulation Expression RRM1 hsa6240
Up-regulation Expression SLC29A1 hsa2030
Down-regulation Expression SNAI2 hsa6591
Down-regulation Expression TWIST1 hsa7291
In Vitro Model PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0480
AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0152
In Vivo Model Each BALB/c nude mouse was subcutaneously inoculated with 5×10⁶ Panc-1 or GR-Panc-1 cells in their right and left hind footpads.
Result Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer
03. Reference
No. Title Href
1 Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer. Mol Med Rep. 2017 Apr;15(4):1461-1470. doi: 10.3892/mmr.2017.6182. Click
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